<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:b04bdee6-11ad-4b6b-8438-ff5da091800d,g:d11a133d-d00f-4f4c-95bd-60372fe6e8be-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://moonlaketx.com/role/Cover" xlink:type="simple" xlink:href="mnlk-20250512.xsd#Cover"/>
  <link:presentationLink xlink:role="http://moonlaketx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_f9bc0d78-26e5-4a43-a3be-43d5217e5450" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_DocumentType_f9bc0d78-26e5-4a43-a3be-43d5217e5450" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_a8ddcea9-8e9d-453c-85b1-1c539c599aa7" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_DocumentPeriodEndDate_a8ddcea9-8e9d-453c-85b1-1c539c599aa7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_e3463aa6-d7fe-40e4-9a8e-d825737d145c" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityRegistrantName_e3463aa6-d7fe-40e4-9a8e-d825737d145c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_f2217601-db37-4788-b9b3-dd921a245472" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityIncorporationStateCountryCode_f2217601-db37-4788-b9b3-dd921a245472" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_5b517cb4-5e84-4071-8329-9bd6b539961f" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityFileNumber_5b517cb4-5e84-4071-8329-9bd6b539961f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_cce7de2f-c709-480a-b029-19a7ae1f3eff" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityTaxIdentificationNumber_cce7de2f-c709-480a-b029-19a7ae1f3eff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_33496282-39ed-4b76-b38a-f588b4c39b01" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityAddressAddressLine1_33496282-39ed-4b76-b38a-f588b4c39b01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_90470626-96ee-41d1-8831-b9adce462d9c" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityAddressPostalZipCode_90470626-96ee-41d1-8831-b9adce462d9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_f059dc74-0f99-481c-bb9e-e262fa8f30a6" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityAddressCityOrTown_f059dc74-0f99-481c-bb9e-e262fa8f30a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_24aa72ac-f11e-4e41-aa80-f562fc71c4d6" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityAddressCountry"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityAddressCountry_24aa72ac-f11e-4e41-aa80-f562fc71c4d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_ec462702-5469-41a1-afed-91ef5f5d6a07" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_CityAreaCode_ec462702-5469-41a1-afed-91ef5f5d6a07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_d737ad07-844d-49ba-9484-2c77357f151d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_LocalPhoneNumber_d737ad07-844d-49ba-9484-2c77357f151d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_08933fe6-4431-457c-ad0f-5a19687449c3" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_WrittenCommunications_08933fe6-4431-457c-ad0f-5a19687449c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_c1949d00-e9f9-4ce6-9511-1d0ae7187335" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_SolicitingMaterial_c1949d00-e9f9-4ce6-9511-1d0ae7187335" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_5432da8f-992f-4fb2-9e95-75d00e6c300e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_PreCommencementTenderOffer_5432da8f-992f-4fb2-9e95-75d00e6c300e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_6a478072-f900-41d5-a493-7c219a03f785" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_6a478072-f900-41d5-a493-7c219a03f785" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_263b8ba7-5426-4aae-b300-c1415d92d037" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_Security12bTitle_263b8ba7-5426-4aae-b300-c1415d92d037" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_c4e652b2-25c5-4c5b-8670-43e825827349" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_TradingSymbol_c4e652b2-25c5-4c5b-8670-43e825827349" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_32ddacca-0a28-4f11-88fe-6007475f6b9d" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_SecurityExchangeName_32ddacca-0a28-4f11-88fe-6007475f6b9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_6e54ee46-c8ee-48be-9f09-c94e42d3146e" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityEmergingGrowthCompany_6e54ee46-c8ee-48be-9f09-c94e42d3146e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_dde4f8b1-bb46-4cd5-a684-677fce1323f2" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_AmendmentFlag_dde4f8b1-bb46-4cd5-a684-677fce1323f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_fe904fed-3a62-4d45-96c0-40e5d01ba362" xlink:href="https://xbrl.sec.gov/dei/2024/dei-2024.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_be6a25f4-41e0-49a3-845c-95d724a9de15" xlink:to="loc_dei_EntityCentralIndexKey_fe904fed-3a62-4d45-96c0-40e5d01ba362" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
