United States securities and exchange commission logo May 16, 2022 Jorge Santos da Silva Founder & Chief Executive Officer MoonLake Immunotherapeutics Dorfstrasse 29 6300 Zug Switzerland Re: MoonLake Immunotherapeutics Amendment No. 3 to Registration Statement on Form S-1 Filed May 2, 2022 File No. 333-262643 Dear Dr. Santos da Silva: We have reviewed your amended registration statement and have the following comments. In some of our comments, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comments apply to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to these comments, we may have additional comments. Amendment No. 3 to Registration Statement on Form S-1 Cover Page 1. For the Class A Ordinary Shares being registered for resale, please revise the cover page to disclose the price that the selling shareholders paid for such shares. 2. We note the significant number of redemptions of your Class A ordinary shares in connection with your business combination and that the shares being registered for resale will constitute a considerable percentage of your public float. To the extent that many of the shares being registered for resale were purchased by the selling shareholders for prices considerably below the current market price of the ordinary shares please highlight here the significant negative impact sales of shares on this registration statement could have on Jorge Santos da Silva FirstName MoonLake LastNameJorge Santos da Silva Immunotherapeutics Comapany May NameMoonLake Immunotherapeutics 16, 2022 May 16, Page 2 2022 Page 2 FirstName LastName the public trading price of the ordinary shares. Introductory Note Regarding the Business Combination, page iv 3. Please revise your disclosure here to also discuss the significant redemption of your Class A ordinary shares that occurred in connection with the business combination, including stating clearly the number of ordinary shares that were redeemed by public shareholders and the percentage of public shareholders who exercised their right to redeem shares. Risk Factors Risks Related to our Class A Ordinary Shares Future resales of Class A Ordinary Shares may cause the market price of the Class A Ordinary Shares to decline significantly, page 35 4. You state here that [f]uture resales of Class A Ordinary Shares may cause the market price of the Class A Ordinary Shares to decline significantly." This statement should be updated given that this prospectus is facilitating those sales. Furthermore, we note that this risk factor highlights the negative pressure potential sales of shares pursuant to this registration statement could have on the public trading price of the Class A ordinary shares. To illustrate this risk, please also disclose here the purchase price of the shares being registered for resale and the percentage that these shares currently represent of the total number of shares outstanding. Also, to the extent applicable, disclose that even though the current trading price is significantly below the SPAC IPO price, the private investors have an incentive to sell because they will still profit on sales because they purchased their shares at a lower price than public investors. Management's Discussion and Analysis of Financial Condition and Results of Operation, page 92 5. Please expand your discussion here to reflect the fact that this offering involves the potential sale of a substantial portion of shares for resale and discuss how such sales could impact the market price of the company s Class A ordinary shares. Your discussion should highlight the fact that BVF Partners L.P., a beneficial owner of 58.91% of your outstanding shares, will be able to sell all of its shares for so long as the registration statement of which this prospectus forms a part is available for use. Liquidity and Capital Resources, page 98 6. We note your disclosure here that as a result of the level of redemptions at the time of consummation of the Business Combination, you now expect to have sufficient capital to fund your operations until at least the next two years rather than through at least the next three and a half years. In light of the significant number of redemptions, expand your discussion of capital resources to address any changes in the company s liquidity position since the business combination. If the company is likely to have to seek additional capital, discuss the effect of this offering on the company s ability to raise additional capital. Jorge Santos da Silva MoonLake Immunotherapeutics May 16, 2022 Page 3 General 7. Please revise your prospectus to disclose the price that each selling shareholder paid for the shares being registered for resale. Highlight any differences in the current trading price, the prices at which the Sponsor, PIPE investors or other selling shareholders acquired their shares, and the price at which the public shareholders acquired their shares. Disclose that while the Sponsor, PIPE investors or other selling shareholders may experience a positive rate of return based on the current trading price, the public shareholders may not experience a similar rate of return on the securities they purchased due to differences in the purchase prices and the current trading price. Please also disclose the potential profit the selling shareholders will earn based on the current trading price, if any. Lastly, please include appropriate risk factor disclosure on these points. You may contact Jessica Ansart at 202-551-4511 or Laura Crotty at 202-551-7614 with any questions. Sincerely, FirstName LastNameJorge Santos da Silva Division of Corporation Finance Comapany NameMoonLake Immunotherapeutics Office of Life Sciences May 16, 2022 Page 3 cc: Branden Berns FirstName LastName